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Home > View Decisions > Funding Decisions Notifications > 2004

 

Operating Grants: sorted alphabetically by Principal Grantee

Results of the 01/03/2004 Operating Grants Competition
Updated : 18/11/2004
Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
ADAMSON, S. L BRUNEAU, Benoit G / OSBORNE, Lucy R
 $250,909 $39,142 1 Yr(s) GMX
ROSSANT, Janet
Mount Sinai Hospital (Toronto)
Samuel Lunenfeld Research Institute (Toronto)
Generation and physiologic analysis of genome- wide mutations in mice
ADAMSON, S. L FOSTER, F. S $170,668 $36,678 4 Yr(s) CIA
Mount Sinai Hospital (Toronto)
Samuel Lunenfeld Research Institute (Toronto)
Cardiovascular phenotyping in embryonic and newborn mice
AL MOUSTAFA, Ala-Eddin $90,646 $32,733 3 Yr(s) CPT
Sir Mortimer B. Davis Jewish General Hospital- Mtl
Lady Davis Institute for Medical Research (Mtl)
HPV, erbB-2 and D-Type cyclin interactions, in vivo and in vitro studies
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
1

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
ALAOUI-JAMALI, Moulay A ARYA, Prabhat $150,282 4 Yr(s) CPT
Sir Mortimer B. Davis Jewish General Hospital- Mtl
Selective targeting of the FAK protein module driving early stage tumour cell invasion
ALLARD, Michael F BROWNSEY, Roger W $134,829 $30,000 5 Yr(s) CSB
University of British Columbia
St. Paul's Hospital, Vancouver
Regulation of carbohydrate oxidation in cardiac hypertrophy
ALLISON, Paul J FRANCO, Eduardo L / FUHRER, Rebecca / HUMPHRIS, Gerald M / NICOLAU, Belinda F / SACKER, Amanda
 $135,444 3 Yr(s) PSB
McGill University
The life course approach to the aetiology of squamous cell carcinoma in the upper aerodigestive tract
AMIR, Shimon $140,618 $16,780 3 Yr(s) BSA
Concordia University (Montreal, Quebec)
Nature, modulation and function of subordinate circadian clocks in the basal forebrain
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
2

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
AMRANI, Abdelaziz $107,026 $19,112 3 Yr(s) IT Pending
Université de Sherbrooke
Mechanisms of autoimmune diabetes resistance induced by granulocyte macrophage-colony stimulating factor (GM- CSF)
ANDERSON, Christopher M $93,098 $23,820 5 Yr(s) NSB
University of Manitoba
St. Boniface General Hospital Research Centre (Winnipeg)
PARP1 effects on bioenergetics and glutamate homeostasis in brain
ANDERSON, James B $78,300 3 Yr(s) MI
University of Toronto
Gene expression and evolution of antifungal drug resistance
ANDREW, Robert D $54,332 3 Yr(s) NSA
Queen's University (Kingston, Ontario)
Neuronal damage and potential protection in the first critical minutes of head trauma
ANDREW, Susan E TRON, Victor A $109,434 $5,000 3 Yr(s) G
University of Alberta
The role of DNA mismatch repair in UVB- induced apoptosis
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
3

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
ANISMAN, Hymie MERALI, Zulfiquar / POULTER, Michael O
 $139,190 5 Yr(s) BSA
Carleton University (Ottawa)
Behavioural and neurochemical responses to acute, subchronic, and chronic intermittent stressors in relation to depression: Moderation by genetic and early life events
ANTEL, Jack P BAR-OR, Amit $125,490 3 Yr(s) CBM
McGill University
Microglia as regulators and effectors of the immune response in the central nervous system
ARCHAMBAULT, Jacques $120,409 $33,291 3 Yr(s) VVP
Institut de recherches cliniques de Montréal
Functions and regulation of human papillomavirus E1 helicase in viral DNA replication and pathogenesis
AROCHA, Jose F HOFFMAN-GOETZ, Laurie $41,568 $6,398 2 Yr(s)
6 Mths
 KTE
University of Waterloo (Ontario)
Health literacy and cancer communication on the internet
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
4

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
ARONSON, Kristan AYOTTE, Pierre / BAJDIK, Christopher D / BROOKS- WILSON, Angela R / LOHRISCH, Caroline / RICHARDSON, Harriet / SENGUPTA, Sandip K / SPINELLI, John J
 $240,953 $40,221 5 Yr(s) PUB
Queen's University (Kingston, Ontario)
Molecular epidemiology of breast cancer
ARSENAULT, Marie COUET, Jacques $110,376 3 Yr(s) CSB
Université Laval
Hôpital Laval (Québec)
Adaptive mechanisms of the heart to volume overload from chronic aortic regurgitation
AUBERT, Isabelle $89,743 3 Yr(s) BCA
MCLAURIN, Joanne
Sunnybrook and Women's College Health Sciences Ctr
Regenerative strategies in a mouse model of Alzheimer's Disease
AUBIN, Jane E COLE, William G / GRYNPAS, Marc D / HENDERSON, Janet E / STANFORD, William L / VOGEL, Wolfgang F
 $232,541 5 Yr(s) CIB
University of Toronto
Identification of genes responsible for human bone disease through mouse mutagenesis
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
5

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
AUBIN, Michèle BERGERON, Rénald / CASTEL, Josette / FILLION, Lise / HUDON, Eveline / LEDUC, Yvan / LEHMANN, François E / REINHARZ, Daniel / VERREAULT, René
 $128,418 $11,500 3 Yr(s)
6 Mths
 HSR
Université Laval
Hôpital Laval (Québec)
Le rôle du médecin de famille dans le suivi de patients atteints de cancer
AUDET, Julie $88,478 3 Yr(s) BMA
University of Toronto
Profiling of notch signaling in single cells
AULD, Vanessa J $127,368 $19,818 3 Yr(s) NSB
University of British Columbia
Glial cell development and function at the Drosophila neuromuscular junction
AUTEXIER, Chantal $121,865 3 Yr(s) BMB
Sir Mortimer B. Davis Jewish General Hospital- Mtl
The structure and function of telomerase RNP complexes: Conservation and divergence of catalytic and regulatory domains
AV-GAY, Yossef $95,098 5 Yr(s) BMA
University of British Columbia
Molecular analysis of Mycobacterium tuberculosis protein kinases and phosphatses
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
6

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
BACKX, Peter H $141,066 5 Yr(s) CSA
University Health Network (Toronto)
Modulation of cardiac function by thyroid hormone
BAENZIGER, John E $143,376 5 Yr(s) BMA
University of Ottawa
Structure/function of the nicotinic acetylcholine receptor in its lipid environment
BAKOVIC, Marica $132,974 3 Yr(s) M
University of Guelph
Regulation and targeted disruption of the CTP: Ethanolaminephosphate cytidylyltransferase (PCYT2) gene
BANDY, Brian J $63,750 $18,314 3 Yr(s) NUT
University of Saskatchewan
Flavonoids as protectors from ascorbate- induced oxidative stress
BARNES, Steven A $109,924 $11,259 5 Yr(s) NSA
Dalhousie University (Nova Scotia)
Synaptic signaling in the retina
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
7

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
BASAK, Ajoy MBIKAY, Majambu / TANPHAICHITR, Nongnuj
 $108,507 3 Yr(s) E
Ottawa Health Research Institute
Role of PC4 in fertilization: Studies using small inhibitors
BATEMAN, Andrew DANIELS, Eugene $112,429 $8,267 5 Yr(s) CBM
McGill University
Royal Victoria Hospital (Montreal)
A role for progranulin in angiogenesis and vasculogenesis
BAUM, Shari R STEINHAUER, Karsten $71,055 $5,904 5 Yr(s) BSC
McGill University
Speech processing subsequent to focal brain damage
BELIK, Jaques $110,188 5 Yr(s) RS
Hospital for Sick Children (Toronto)
Airway modulation of pulmonary vascular tone during development and following pulmonary hypertension
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
8

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
BELIN, Pascal $73,473 $6,600 3 Yr(s) BSC
ARMONY, Jorge
Université de Montréal
Processing of non-speech emotional vocalizations in humans: Behavioural and neuroimaging studies
BENNETT, David J GORASSINI, Monica A $155,716 5 Yr(s) MOV
University of Alberta
Neuronal mechanisms of spasticity after spinal cord injury: Animal studies
BERGERON, Sophie BENAZON, Nili R / BINIK, Yitzchak Irving M / DUPUIS, Marie-Josée / KHALIFE, Samir
 $83,108 $6,150 3 Yr(s) PSB
Université du Québec à Montréal
Dyadic determinants of pain and related psychosexual impairment in women with vulvar vestibulitis syndrome
BIRNIE, David H RUDDY, Terrence D / TANG, Anthony S / WELLS, George A
 $66,662 3 Yr(s) CSB
University of Ottawa
University of Ottawa Heart Institute
Importance of mechanical dyssynchrony and resynchronization therapy in advanced heart failure patients
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
9

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
BLAIS, Lucie BEAUCHESNE, Marie- France / FORTIER, Isabel / MALO, Jean-Luc / PERREAULT, Sylvie S / REY, Evelyne E
 $60,525 $3,000 3 Yr(s) POP
MARTEL, Marie-Josée
Université de Montréal
Asthma during pregnancy and the incidence of asthma in the offspring
BONEN, Arend $120,250 5 Yr(s) M
University of Guelph
Regulation of skeletal muscle fatty acid transport and transporters
BORASTON, Alisdair B $98,748 $12,407 4 Yr(s) BMA
University of Victoria (British Columbia)
Carbohydrate-recognition in bacterial pathogenesis: New bacterial adhesins and carbohydrate-binding modules in virulence associated bacterial enzymes
BOUCHARD, Guylaine $89,741 3 Yr(s) EM
Hôpital Sainte-Justine (Montréal)
Genetic and biophysical approaches to study the molecular basis of hepatobiliary liver diseases
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
10

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
BOURBONNAIS, Daniel BERTRAND, Martine / MERCIER, Catherine
 $18,140 $7,790 3 Yr(s) MOV
Université de Montréal
Institut de réadaptation de Montréal
Effects of unilateral weakness following stroke on motor prediction and coordination during bilateral tasks
BOYDELL, Katherine M ADDINGTON, Jean M / GLADSTONE, Brenda M / GOERING, Paula N / KRUPA, Terry / MCCAY, Elizabeth A / VOLPE, Tiziana
 $59,860 $5,748 3 Yr(s) HSI Pending
Hospital for Sick Children (Toronto)
Youth experiencing first-episode psychosis: A comprehensive examination of pathways to care
BRANDL, Christopher J $123,274 5 Yr(s) BMB
University of Western Ontario
Function and regulation of the spt/ada transcriptional regulatory complexes in Saccharomyces cerevisiae
BRASH, John L $127,573 3 Yr(s) BME
McMaster University
Studies of blood material interactions and the development of blood compatible materials
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
11

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
BREHAUT, Jamie C CRANNEY, Ann B / LINDGAARD, Gitte
 $131,779 $5,920 3 Yr(s) KTE
TUGWELL, Peter S
O'CONNOR, Annette M
Ottawa Health Research Institute
Improving decision quality in people with arthritis
BROOKS-WILSON, Angela R CONNORS, Joseph M / GASCOYNE, Randy D / SPINELLI, John J
 $130,698 3 Yr(s) G
University of British Columbia
British Columbia Cancer Agency (Vancouver)
Double stranded break surveillance genes and susceptibility to non-Hodgkin lymphoma
BROTTO, Lori Anne $50,171 $12,970 3 Yr(s) PSB
University of British Columbia
Cervical cancer and sexuality: Effects of a psychoeducational intervention and sildenafil on sexual arousal, relationship satisfaction, and quality of life after hysterectomy
BURNS, Peter N WILSON, Stephanie R $110,770 4 Yr(s) BME
Sunnybrook and Women's College Health Sciences Ctr
Tumour angiogenesis imaging using ultrasound contrast agents
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
12

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
BURROWS, Lori L $126,728 $13,775 3 Yr(s) MI
Hospital for Sick Children (Toronto)
"Rod and reel": Investigation of Pseudomonas aeruginosa Type IV pilus assembly and function
BURT, Helen M $94,598 3 Yr(s) PS
University of British Columbia
Inhibition of drug efflux transport proteins by amphiphilic diblock copolymers: Effects on drug permeation and bioavailability
BURT, Helen M $92,364 3 Yr(s) PS
University of British Columbia
Crystal-induced inflammation: Neutrophil activation and repression of apoptosis by crystals
BUSHNELL, Mary C BENNETT, Gary J / FITZCHARLES, Mary-Ann
 $114,653 3 Yr(s) BSC
McGill University
Endogenous pain modulation in patients with fibromyalgia
BYERS, David M $93,697 $5,636 3 Yr(s) BMA
Dalhousie University (Nova Scotia)
Role of acyl carrier protein in bacterial growth and pathogenesis
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
13

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
CAIRNEY, John BOYLE, Michael H / GOERING, Paula N / LIN, Elizabeth / STREINER, David L / WADE, Terrance J
 $26,362 $2,500 1 Yr(s) POP
University of Toronto
Mental health care use among single and married mothers
CARLEN, Peter L $94,322 $29,318 5 Yr(s) NSA
University Health Network (Toronto)
Toronto Western Hospital
The ischemic synapse
CARTER, Jacqueline C CROSBY, Ross / KAPLAN, Allan S / OLMSTED, Marion P / WOODSIDE, D. B
 $51,335 $3,275 3 Yr(s) BSB
University Health Network (Toronto)
A longitudinal study of relapse and recovery in anorexia nervosa
CASEY, Joseph (Joe) R $147,671 $5,371 5 Yr(s) BMA
University of Alberta
Structure and function of anion exchange proteins
CASEY, Joseph (Joe) R $125,448 $21,160 3 Yr(s) CP
University of Alberta
Molecular physiology of sodium/bicarbonate co-transporters
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
14

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
CAZA, Nicole $47,741 3 Yr(s) BCA
Institut universitaire de gériatrie de Montréal
The relation between word processing and short-term/working memory impairments in Alzheimer's Disease and aging
CHAKIR, Jamila $115,362 5 Yr(s) RS
Université Laval
Hôpital Laval (Québec)
Regulation of epithelium repair by bronchial fibroblasts: Role of TGF-beta and EGF
CHAKRABORTY, Chandan $76,852 3 Yr(s) PT
University of Western Ontario
Regulation of human trophoblast migration
CHALLIS, John R
BLOOMFIELD, Francis H / GLUCKMAN, Peter D / MATTHEWS, Stephen G / NEWNHAM, John P
 $218,220 5 Yr(s) E
University of Toronto
Control of parturition
CHALLIS, John R GIBB, William / LYE, Stephen J / MACCALMAN, Colin D / RURAK, Danny W
 $158,490 5 Yr(s) CIA
University of Toronto
Regulation of prostaglandin synthesis, metabolism and action in pregnancy and parturition
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
15

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
CHAMBERS, Christine T CORKUM, Penny V / RUSAK, Benjamin
 $87,796 $500 3 Yr(s) CHI
IWK Health Centre (Halifax)
Sleep disturbances among children with chronic pain
CHANG, Thomas Ming Swi M $98,328 5 Yr(s) PS
McGill University
Novel artificial cells of macro, micro, nano and molecular dimensions as carriers for bioencapsulation of enzymes, cells and stem cells for therapeutic uses
CHARTRAND, Pascal $101,870 $11,630 3 Yr(s) CP
Université de Montréal
The budding yeast as a model system to study mRNA transport and localization
CHEN, Robert $110,166 $11,602 5 Yr(s) MOV
University Health Network (Toronto)
Toronto Western Research Institute (Toronto)
Pathophysiology of Parkinson's Disease
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
16

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
CHOINIÈRE, Manon CARRIER, Michel / COGAN, Jennifer / COLLET, Jean-Paul / COSTELLO, Judy B / FEINDEL, Christopher M / GUERRIERE, Denise N / GUERTIN, Marie-Claude / KING, Kathryn M / LESPERANCE, François / MAITLAND, Andrew / SULLIVAN, John A
 $179,540 $11,416 3 Yr(s)
5 Mths
 PSB
WATT-WATSON, Judith (Judy) H
Montréal Heart Institute
Risks factors in the transition of acute to chronic pain after cardiac surgery - the CARDPAIN study
CLANDININ, Michael T RYAN, Edmond A / SHAPIRO, James A / THOMSON, Alan B
 $125,774 $2,600 3 Yr(s) NUT
University of Alberta
Diet intervention to reduce LDL cholesterol in diabetic patients after islet transplantation
CLARKE, Anthony J
$120,179 5 Yr(s) MI
University of Guelph
Structure and function relationship of lytic transglycosylases and penicillin-binding proteins
COCHRANE, Alan W $100,724 $25,500 5 Yr(s) VVP
University of Toronto
Controlling HIV-1 gene expression
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
17

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
COHEN, Eric A $148,000 5 Yr(s) VVP
Institut de recherches cliniques de Montréal
Study of processes leading to the establishment of HIV-1 infection: Role of the Vpr accessory protein
COHN, Jeffrey S $89,509 3 Yr(s) M
Institut de recherches cliniques de Montréal
Metabolic regulation of apoE production in humans
COLAVITA, Antonio $119,002 3 Yr(s) DEV
Ottawa Health Research Institute
Genetic and molecular analysis of a peptide N- glycanase involved in C. elegans axon branching
COLE, Martin G CIAMPI, Antonio / MCCUSKER, Jane
 $25,284 $3,000 1 Yr(s) BCA
McGill University
St. Mary's Hospital Center (Montreal)
Delirium in elderly medical inpatients: Further analysis of available data
COOK, Linda S FAUGHT, Wylam / MAGLIOCCO, Anthony M
 $148,091 $26,802 5 Yr(s) POP
University of Calgary
High androgen/low progesterone exposures and ovarian cancer
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
18

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
COPELAND, John W $92,589 3 Yr(s) CP
University of Ottawa
Activation of the transcription factor SRF by formin homology proteins
CORNELL, Rosemary B $106,010 3 Yr(s) M
Simon Fraser University (Burnaby, B.C.)
Regulation of cytidylyltransferase by membrane binding
COTE, Jocelyn $98,762 $15,750 3 Yr(s) CBM
University of Ottawa
A role for the tudor domain of SMN and arginine methylation in spinal muscular atrophy
CRAIG, Ann Marie $162,454 5 Yr(s) NSA
University of British Columbia
Molecular dynamics at the postsynaptic density
CRAWFORD, John D $123,543 5 Yr(s) BSC
York University (Toronto, Ontario)
Parietal mechanisms for eye-hand coordination in the human
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
19

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
CREGAN, Sean P $93,180 3 Yr(s) NSA
John P. Robarts Research Institute (London, Ont.)
Mechanisms of bax activation in injury induced neuronal cell death
CUPPLES, Claire G $73,108 4 Yr(s) G
University of Victoria (British Columbia)
Role of mutL in the regulation of DNA mismatch repair
DANIEL, Claude $119,433 3 Yr(s) IT
INRS - (Ste. Foy, Québec)
INRS-Institut Armand-Frappier (Laval)
Visualization and modulation of T cell immune responses in allograft rejection
DAVEY, Megan J $91,627 $15,247 5 Yr(s) BMB
University of Western Ontario
Mechanisms of DNA replication: Helicase loading and activation
DAVID, Samuel $140,755 $11,335 5 Yr(s) CBM
The Res. Inst. of the McGill University Health Ctr
Regulation of iron homeostasis in the CNS: Implications for neurodegeneration
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
20

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
DAVIDSON, Alan R $113,261 3 Yr(s) BMB
University of Toronto
Quantitative in vitro and in vivo analysis of the role of protein-protein interactions in signal transduction
DE CHAMPLAIN, Jacques $141,510 3 Yr(s) CSC
Université de Montréal
Modulation of the sympathetic system and its signal transduction mechanisms by reactive oxygen species in experimental hypertension and diabetes
DE KONINCK, Paul $95,022 3 Yr(s) NSA
Université Laval
Centre de recherche Université Laval-Robert- Giffard (QC)
Synaptic signaling and remodeling by CaM kinase II
DE NIL, Luc F CRAWLEY, Adrian P / GRACCO, Vincent / KROLL, Robert M.
 $82,344 $7,135 5 Yr(s) BSC
University of Toronto
Neuroimaging studies of auditory processing in individuals who stutter
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
21

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
DEANS, Julie P $152,875 $5,000 5 Yr(s) IT
University of Calgary
Molecular analysis of the CD20-regulated calcium channel and its role in B cell activation
DEBLOIS, Denis $110,098 $22,272 3 Yr(s) PT
Centre Hosp. de l'Université de Montréal (CHUM)
Therapeutic apoptosis : Regulation and significance in controling cardiovascular organ damage
DELISLE, Hélène F GARREL, Dominique R / GHADIRIAN, Parviz / POEHLMAN, Eric T
 $105,538 3 Yr(s) POP
Université de Montréal
The impact of transition to westernized diets and lifestyles on obesity and other cardiovascular disease risk markers in Africans living in Benin, in Haiti and in Montreal
DESCOTEAUX, Albert $98,615 3 Yr(s) MI
INRS - (Ste. Foy, Québec)
INRS-Institut Armand-Frappier (Laval)
Role of PKC isoenzymes in the regulation of macrophage functions
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
22

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
DESROSIERS, Johanne DEMERS, Louise / GELINAS, Isabelle / NOREAU, Luc / ROBICHAUD, Line A
 $84,516 2 Yr(s) SDA
Université de Sherbrooke
Participation sociale et stratégies compensatoires dans le vieillissement normal
DEWAILLY, Éric JULIEN, Pierre / YOUNG, Kue
 $105,111 2 Yr(s) POP
Université Laval
Inuit health in transition study: Nunavik study
DI PAOLO-CHENEVERT, Thérèse BEDARD, Paul J / RAJPUT, Alexander H
 $136,172 $11,000 5 Yr(s) NSA
Université Laval
Centre hospitalier de l'Université Laval (Québec)
Molecular correlate of levodopa-induced dyskinesia
DIRKS, Peter B $141,065 3 Yr(s) MCC
Hospital for Sick Children (Toronto)
Cellular and molecular characterization of cancer stem cells in human brain tumours
DONE, Susan J PINTILIE, Melania / SWEET, Joan M / WILSON, Christine M
 $81,494 3 Yr(s) CPT
University Health Network (Toronto)
The effect of COX-2 inhibition on the progression of pre-invasive breast cancer
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
23

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
DORRIS, Michael C $92,000 3 Yr(s) BSC
Queen's University (Kingston, Ontario)
Probing the neural basis of decision-making
DROBETSKY, Elliot A $101,398 $10,805 3 Yr(s) G
Hôpital Maisonneuve-Rosemont (Montréal)
Regulation of nucleotide excision repair in human cells
DROUIN, Jacques $164,482 3 Yr(s) G
Institut de recherches cliniques de Montréal
Glucocorticoid repression of transcription and implication in Cushing Disease/tumours
DUBOIS, Claire M DAY, Robert $107,962 3 Yr(s) CBM
Université de Sherbrooke
Role of hypoxia-inducible factor (HIF-1) in the molecular regulation/activation of the metalloprotease TACE in joint diseases
DUBUC, Réjean $158,011 5 Yr(s) NSB
Université du Québec à Montréal
Université de Montréal
Supraspinal control of locomotion in lampreys
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
24

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
DUGAS, Michel J PHILLIPS, Natalie A / RADOMSKY, Adam S
 $52,237 3 Yr(s) PSB
Concordia University (Montreal, Quebec)
Hôpital du Sacré-Coeur de Montréal
Intolerance of uncertainty and fear of anxiety in generalized anxiety disorder: Cognitive processing in nonclinical and clinical samples
DUMONT, Marie $110,809 $4,112 3 Yr(s) BSC
Hôpital du Sacré-Coeur de Montréal
Régulation du sommeil et de la vigilance par l'oscillateur circadien
DUMONT, Serge BRENNEIS, Carleen / BURGE, Frederick I / DESCHAMPS, Michèle / FAINSINGER, Robin L / HARLOS, Michael S / JOHNSTON, Grace M / MCMANUS, Lorena / PENROD, John R / STAJDUHAR, Kelli I
 $134,757 $5,000 2 Yr(s) HPM
JACOBS, Philip
FASSBENDER, Konrad
VILLENEUVE, Patrick
Université Laval
Centre hospitalier de l'Université Laval (Québec)
Palliative care in Canada: The economic perspective
DUNCAN, Roy $138,194 $31,090 5 Yr(s) VVP
Dalhousie University (Nova Scotia)
Structure-function analysis of the reovirus p10 FAST proteins
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
25

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
DUTZ, Jan P ZHOU, Youwen $127,958 3 Yr(s) CIB
University of British Columbia
B.C. Research Institute for Children
Chemoimmunotherapy and CTL priming to treat malignant melanoma
EISENSTAT, David D $118,580 3 Yr(s) CPT
University of Manitoba
Role of mutant BNIP3 in malignant gliomas
ENGERT, James C HUDSON, Thomas J / PASTINEN, Tomi
 $78,993 3 Yr(s) GMX
The Res. Inst. of the McGill University Health Ctr
Royal Victoria Hospital (Montreal)
Haplotype block structure predicts quantitative phenotypic differences
ERVIN, Frank R BAKER, Glen B / BENKELFAT, Chawki / PALMOUR, Roberta M / PTITO, Maurice / YOUNG, Simon N
 $106,006 $26,063 3 Yr(s) BSA
McGill University
The agony of ecstasy: Neurobiological characterization of a non-human primate model of MDMA abuse
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
26

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
ESCHER, Emanuel $95,564 5 Yr(s) PT
Université de Sherbrooke
Développement et utilisation d'outils moléculaires pour l'étude de récepteurs peptidergiques
ETHIER, C. R $108,965 $43,070 4 Yr(s) CIA
University of Toronto
Factors controlling aqueous outflow resistance in glaucoma
EUBANKS, James H BURNHAM, W. M / SNEAD, Orlando C
 $117,137 5 Yr(s) BSA
University Health Network (Toronto)
Toronto Western Hospital
Towards the correction of rett-like behavior in meCP2-deficient mice by exogenous gene transfer
FEDIDA, David $144,000 $33,168 5 Yr(s) CSA
University of British Columbia
Molecular mechanisms for the gating of voltage-activated potassium channels
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
27

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
FELDMAN, Debbie BERNATSKY, Sasha R / LEFFONDRE, Karen / TOUSIGNANT, Pierre
 $77,872 3 Yr(s) HPM
ABRAHAMOWICZ, Michael M
Université de Montréal
Optimal care trajectories in rheumatoid arthritis: The primary - secondary interface
FERBEYRE, Gerardo $113,509 $31,000 5 Yr(s) MCC
Université de Montréal
Cellular senescence as a model system to dissect tumour suppression pathways
FERGUSON, Alastair V $133,269 5 Yr(s) NSA
Queen's University (Kingston, Ontario)
Prokineticin 2: A circadian regulator of central autonomic control
FLETCHER, Paul J $71,603 5 Yr(s) BSA
The Centre for Addiction and Mental Health (Toronto)
Serotonin-dopamine interactions and reward: The role of 5-HT2C receptors
FLIEGEL, Larry $104,500 $6,000 5 Yr(s) CSA
University of Alberta
The Na+/H+ exchanger and heart hypertrophy
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
28

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
FOURNIER, Alain $76,385 $26,850 3 Yr(s) PT
INRS - (Ste. Foy, Québec)
INRS-Institut Armand-Frappier (Pointe-Claire)
Molecular pharmacology of urotensin II, a cardiovascular peptide hormone
FRANCO, Eduardo L COUTLÉE, François / HANLEY, James A / TELLIER, Pierre-Paul
 $108,609 $3,500 5 Yr(s) POP
McGill University
HPV infection and transmission among couples through heterosexual activity (the HITCH cohort)
FRENETTE, Jérôme COTE, Claude H $87,659 3 Yr(s) MOV
Université Laval
Inflammatory cell recruitment and function in skeletal muscles following hindlimb unloading and reloading: New strategies to prevent muscle atrophy and dysfunction
FROST, Laura S $124,696 5 Yr(s) MI
University of Alberta
Regulation of F plasmid transfer
FUNK, Colin D $135,516 5 Yr(s) PT
Queen's University (Kingston, Ontario)
Leukotrienes in health and disease
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
29

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
GAGNON, Anita J DENNIS, Cindy-Lee E / DOUGHERTY, Geoffrey / GEORGE, M. Anne / OXMAN-MARTINEZ, Jacqueline / SAUCIER, Jean-François / STANGER, Elizabeth A / STEWART, Donna E / WAHOUSH, Ellen O
 $502,389 $70,062 4 Yr(s) HPM Pending
McGill University
The childbearing health and related service needs of newcomers (CHARSNN)
GAGNON, France BULMAN, Dennis E / WELLS, Philip S
 $130,015 $10,845 3 Yr(s) G
University of Ottawa
Search for modifier genes in familial thrombophilia with factor V leiden mutation: A look at the haemostatic pathways
GAISANO, Herbert Y TSUSHIMA, Robert G $113,310 5 Yr(s) CP
University of Toronto
SNARE regulation of potassium channels in pancreatic islet beta cells
GALBAUD DU FORT, Guillaume BOIVIN, Jean-François / COLLET, Jean-Paul / LOOPER, Karl J / ROSBERGER, Zeev
 $74,846 $3,709 3 Yr(s) HSI
Sir Mortimer B. Davis Jewish General Hospital- Mtl
Screening for depression in breast cancer patients: Acute distress versus persistent distress
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
30

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
GALIPEAU, Jacques $138,634 5 Yr(s) CPT
Sir Mortimer B. Davis Jewish General Hospital- Mtl
Lady Davis Institute for Medical Research (Mtl)
Cancer cell and gene therapy - A study of novel chimeric anti-cancer immunomodulatory transgenes and transgenic cell therapy
GAYNOR, Erin C $103,372 3 Yr(s) MI
University of British Columbia
Molecular mechanisms of the Campylobacter jejuni-host cell interaction
GEORGE, Graham N PICKERING, Ingrid J $114,312 5 Yr(s) BMA Pending
University of Saskatchewan
The molecular basis of mercury toxicity
GERMAIN, Lucie $132,922 5 Yr(s) CIB
Université Laval
Régénération différentielle de la peau humaine: Voies de spécialisation des cellules souches cutanées
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
31

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
GIACCA, Adria FANTUS, Ivan G $100,436 3 Yr(s) M
University of Toronto
Interaction between glucotoxicity and lipotoxicity on glucose stimulated insulin secretion
GIBSON, Spencer B $116,391 3 Yr(s) MCC Pending
University of Manitoba
MEK kinase 1 (MEKK1) is a molecular switch regulating apoptosis and cell survival
GLASS, Kathleen C CROUCH, Robert A / FERGUSSON, Dean A / HEBERT, Paul C / SHAPIRO, Stanley H
 $83,735 3 Yr(s) ELH
McGill University
Advancing the ethics of clinical trials: Enhancing participant protection and scientific rigour
GLOVER, John R $117,188 3 Yr(s) CP
University of Toronto
Structure, function, and biology of the chaperone hsp104
GODBOUT, Roseline $116,550 3 Yr(s) CBM
University of Alberta
The role of AP-2 in retinal differentiation and retinoblastoma
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
32

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
GOLD, Michael R $130,174 3 Yr(s) IT
University of British Columbia
The role of the rap GTPases in B cell adhesion and migration
GOODYER, Cindy G $95,892 3 Yr(s) E
The Res. Inst. of the McGill University Health Ctr
Montreal Children's Hospital Research Institute
The human growth hormone receptor: Regulation of expression during development
GORASSINI, Monica A $115,719 5 Yr(s) MOV
University of Alberta
Neuronal mechanisms of spasticity after spinal cord injury: Human studies
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
33

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
GRAHAM, Ian D ANGUS, Douglas E / BROUWERS, Melissa C / DAVIES, Barbara L / DRIEDGER, S. Michelle / ECCLES, Martin P / GODIN, Gaston / GRIMSHAW, Jeremy M / HARRISON, Margaret B / LEGARE, France / LEMYRE, Louise / MCGOWAN, Jessie / POMEY, Marie-Pascale A / STACEY, Dawn / TETROE, Jacqueline M / WENSING, Michel J
 $83,763 $4,000 1 Yr(s) KTE
LOGAN, Jo F
Ottawa Health Research Institute
Identification, concept and bibliometric analyses of knowledge translation theories/frameworks
GRAY-DONALD, Katherine A COUTSOUDIS, Anna $45,689 3 Yr(s) NUT
McGill University
University of Natal (South Africa)
Safety, efficacy and acceptability of expressed heat-treated breast milk use by HIV-1 infected women in South Africa
GREER, Peter A $153,998 5 Yr(s) MCC
Queen's University (Kingston, Ontario)
A molecular and genetic analysis of the fer proto-oncogene
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
34

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
GROSS, Peter L $75,797 3 Yr(s) EM
St. Michael's Hospital (Toronto)
Thrombus fibrinolysis: Cell-adhesion molecule dependent delivery of plasminogen activators to arterial thrombi in vivo
GRUNAU, Ruth E OBERLANDER, Timothy F / WEINBERG, Joanne
 $112,453 3 Yr(s) BSA
University of British Columbia
BC Research Institute for Children's & Women's Health
Biobehavioural responses during immunization in preterm infants
GRYMONPRE, Ruby E $75,292 2 Yr(s) SDA
University of Manitoba
Prescription medication adherence among older Manitobans: Aging in Manitoba, 1996 -2001
GUAY, Frédéric BOIVIN, Michel / LAROSE, Simon / TREMBLAY, Richard E / VITARO, Frank
 $60,683 $978 3 Yr(s) CHI
Université Laval
Étude des facteurs psychosociaux associés à la réussite et à l'adaptation scolaires des élèves de niveau primaire
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
35

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
GUERIN, Sylvain L SALESSE, Christian $116,182 $11,878 3 Yr(s) CIA
Université Laval
Centre hospitalier de l'Université Laval (Québec)
Molecular and cellular mechanisms modulating integrins expression during corneal wound healing
GUERTIN, Pierre $68,981 $4,600 3 Yr(s) BSA
Université Laval
Centre hospitalier de l'Université Laval (Québec)
Role of serotonin receptor subtypes in induction of hindlimb stepping in paraplegic mice
GUILBERT, Larry J BAKER, Philip / DAVIDGE, Sandra T
 $88,328 3 Yr(s) CIA
University of Alberta
The balance between placental cell death and tissue remodeling in IUGR preeclampsia
GUILLEMETTE, Chantal PLANTE, Marie $100,724 3 Yr(s) E
BELANGER, Alain
Université Laval
Centre hospitalier de l'Université Laval (Québec)
Metabolic profiling of estradiol in women
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
36

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
GUILLEMETTE, Gaétan $90,966 3 Yr(s) PT
Université de Sherbrooke
Mécanismes de régulation des récepteurs de l'inositol 1,4,5-trisphosphate
HAAS, Thomas A $110,860 $22,934 3 Yr(s) CPT
University of Saskatchewan
Uncoupling of integrin alphaVbeta3 expression and function in cancer
HACHE, Robert J $133,531 3 Yr(s) BMB
Ottawa Health Research Institute
Convergence of DNA-dependent protein kinase and high mobility group proteins in the regulation of nuclear events
HAGHIGHI, Ali Pejmun $105,723 3 Yr(s) NSA
McGill University
Regulation of synaptic growth and function at the Drosophila neuromuscular junction: Anterograde and retrograde mechanisms
HAMEL, Paul A $145,614 5 Yr(s) MCC
University of Toronto
LEF1 and alx4 during development and malignant transformation of the mammary gland
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
37

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
HAMPTON, Mary R FARRELLRACETTE, Sherry / JEFFERY, Bonnie L / MCWATTERS, Barbara
 $82,736 $3,800 1 Yr(s) HSI
University of Regina (Saskatchewan)
Strengthening and building sexual health of aboriginal youth and young adults
HANNIGAN, Gregory E $105,382 3 Yr(s) CBM
Hospital for Sick Children (Toronto)
The role of ILK associated proteins in cell adhesion and signaling
HARRISON, Rene E $104,639 3 Yr(s) IT
University of Toronto
Functional roles and molecular regulation of the microtubule cytoskeleton in phagocytosis and antigen-presentation
HOLLOWAY, Alison C MORRISON, Katherine Mary
 $106,461 3 Yr(s) CIA
McMaster University
In utero exposure to nicotine and postnatal health consequences
HORACEK, Bohumil M CLEMENTS, John C / GARDNER, Martin J / SAPP, John L
 $88,102 $2,919 3 Yr(s) BME
Dalhousie University (Nova Scotia)
Spatiotemporal dynamics of ventricular tachycardia and ventricular fibrillation in a three-dimensional anisotropic heart model
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
38

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
HORB, Marko E $96,440 3 Yr(s) E
Institut de recherches cliniques de Montréal
The role of ptf1a and pdx1 in the conversion of liver to pancreas
HOWLETT, Susan E $134,591 $10,642 5 Yr(s) BCA
Dalhousie University (Nova Scotia)
Excitation-contraction coupling in aging and diseased heart
HUGHES, Timothy R $130,348 5 Yr(s) BMB
University of Toronto
Genomic and proteomic analysis of noncoding RNA processing and regulation
HUNTER, Graeme K $96,984 3 Yr(s) DS Pending
GOLDBERG, Harvey A
University of Western Ontario
Significance of osteopontin phosphorylation in matrix-mineral and cell-matrix interactions
HUNTSMAN, David G BAJDIK, Christopher D / GELMON, Karen A
 $73,299 3 Yr(s) CPT
University of British Columbia
The clinical implications of EMSY gene amplification events
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
39

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
IGDOURA, Suleiman A $125,018 3 Yr(s) G
McMaster University
The role of sialidase in the pathogenesis of neurodegenerative diseases
IKURA, Mitsuhiko $145,964 $13,522 5 Yr(s) BMA
University Health Network (Toronto)
Structural biology of calcium sensing systems
IKURA, Mitsuhiko $123,050 $15,751 3 Yr(s) BMA
University Health Network (Toronto)
Structural basis for transcriptional regulation
INMAN, Robert D $110,252 3 Yr(s) CIB
University Health Network (Toronto)
Experimental reactive arthritis: Interplay of infection and autoimmunity
ISENRING, Paul $96,190 $16,000 3 Yr(s) CSA
Université Laval
Hôtel-Dieu de Québec
Molecular mechanisms underlying the normal operation and the physiological role of the renal Na-K-Cl cotransporter splice variants
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
40

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
JACOBS-KAUFMAN, Susan E $131,575 $27,099 5 Yr(s) CSB
University of Alberta
Splanchnic control of cardiorenal homeostasis
JARDIM, Armando P $89,828 3 Yr(s) MI
McGill University
Glycosome biogenesis: Analysis of protein targeting and import
JEAN-CLAUDE, Bertrand J MZENGEZA, Shadreck / SOUCY, Jean-Paul
 $133,508 3 Yr(s) CPT
McGill University
The combi-targeting concept: Positron emission tomography (PET) imaging and radiotracing of antitumour combi-molecules designed to spontaneously block the action of the erb gene products and to damage genomic DNA
JEAN-CLAUDE, Bertrand J $92,860 5 Yr(s) PT
McGill University
Royal Victoria Hospital (Montreal)
Novel unimolecular combination models for selective tumour targeting: A tandem approach to the enhancement of chemoselectivity and abrogation of chemoresistance
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
41

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
JEANNOTTE, Lucie $126,755 4 Yr(s) DEV
Université Laval
Hôtel-Dieu de Québec
Developmental mechanisms of hoxa5 gene regulation
JEEJEEBHOY, Khursheed N $95,700 $30,000 3 Yr(s) NUT
University of Toronto
Nutritional modulation of endotoxin mediated cachexia: Role of apoptosis
HURLEY, Jeremiah E CROSSLEY, Thomas / HUTCHISON, Brian G / JEON, Sung-Hee / MARTIN, Shelley
 $45,189 $2,500 1 Yr(s)
4 Mths
 HPM
McMaster University
Physician labour supply in Canada: A cohort analysis
JIA, Zongchao $106,049 2 Yr(s) BMA
Queen's University (Kingston, Ontario)
Structure-based functional studies of cancer- related proteins
JIN, Tianru $101,120 $20,000 3 Yr(s) M
University Health Network (Toronto)
Cell type specific regulation of proglucagon gene expression - role of cat/TCF and insulin
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
42

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
JOANISSE, Denis R MARETTE, André / TREMBLAY, Angelo / WEISNAGEL, Stanley J
 $115,545 3 Yr(s) NUT
Université Laval
Intramyocellular lipids and insulin resistance in human obesity and diabetes
JOHNSON, James D $94,500 $15,000 3 Yr(s) M
University of British Columbia
Intracellular calcium stores as master regulators of pancreatic beta-cell survival: Studies on transplantable human islets and knockout mice
JOHNSRUDE, Ingrid S $81,307 3 Yr(s) BSC
Queen's University (Kingston, Ontario)
From sound to meaning: The neural and functional bases of speech perception studied using fMRI
JOHNSTON, Miles G $118,056 $3,510 3 Yr(s) NSA
Sunnybrook and Women's College Health Sciences Ctr
Does interference with cerebrospinal fluid transport into the lymphatic system contribute to the pathogenesis of hydrocephalus
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
43

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
JOHRI, Mira POGGE, Thomas $16,940 $3,500 2 Yr(s) ELH
ORBINSKI, James J
Université de Montréal
Access to essential medicines in developing countries: Defining Canadian and global responsibilities
JUURLINK, David N AUSTIN, Peter C / ETCHELLS, Edward E / LAUPACIS, Andreas / MAMDANI, Muhammad M
 $32,768 2 Yr(s) HSR
Sunnybrook and Women's College Health Sciences Ctr
Drug interactions in clinical practice
KABANI, Noor J $57,960 $10,000 3 Yr(s) BCA
Sunnybrook and Women's College Health Sciences Ctr
Anatomy of dementia in aging: An MRI study of comparative changes in brain structures in Alzheimer's Disease, mild cognitive impairment, frontotemporal and Lewy Body Dementia
KABLAR, Boris $61,722 3 Yr(s) CBM
Dalhousie University (Nova Scotia)
Skeletal muscle influence on neural development
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
44

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
KAN, Frederick W $101,699 3 Yr(s) E
Queen's University (Kingston, Ontario)
Oviductal regulation of gamete interaction and fertilization
KAPLAN, Feige SWEEZEY, Neil B $131,119 5 Yr(s) RS
The Res. Inst. of the McGill University Health Ctr
Montreal Children's Hospital Research Institute
Mechanisms of action of lgl1 in lung branching and alveogenesis
KAPUR, Shitij BECKER, Helen S / MIKULIS, David J / ZIPURSKY, Robert B
 $108,619 $9,961 3 Yr(s) BSB
The Centre for Addiction and Mental Health (Toronto)
The Centre for Addiction & Mental Health (Toronto)
Schizophrenia, reward learning and reward prediction errors - A study using computational models and event related fMRI
KAR, Satyabrata $110,772 3 Yr(s) NSB
University of Alberta
Amyloid beta peptides, glycogen synthase kinase-3beta and cholinergic neurons: Functional interrelationships and implications in Alzheimer's Disease
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
45

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
KAVANAGH, Brian Patrick W $104,652 $12,400 5 Yr(s) RS
Hospital for Sick Children (Toronto)
Preclinical assessment of therapeutic hypercapnia
KAY, Robert J $117,336 3 Yr(s) CP
University of British Columbia
B.C. Cancer Research Centre (Vancouver)
Role of ras GRPs in BCR-included deletion of immature B cells
KHANDJIAN, Edward W $88,495 $5,200 5 Yr(s) G
Université Laval
Hôpital Saint-François d'Assise (Québec)
Function of the FMR1 gene product in protein synthesis
KHATIB, Abdel-Majid $99,398 2 Yr(s) CPT
Ottawa Health Research Institute
Substrates and downstream effectors of convertases in carcinoma and metastasis
KIEFFER, Timothy J $98,639 3 Yr(s) M
University of British Columbia
Leptin regulation of glucose homeostasis
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
46

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
KIM, Sung O $103,794 3 Yr(s) MI
London Health Sciences Centre Res. Inc. (Ont.)
Anthrax lethal toxin-induced cell death of activated macrophages
KING, Graham John W JOHNSON, James A $99,959 $29,975 5 Yr(s) BME
University of Western Ontario
Kinematics and stabilizers of the elbow
KIROUAC, Gilbert J $76,126 3 Yr(s) BSA
Memorial University of Newfoundland
Regulation of orexin (hypocretin) neurons by monoaminergic and cholinergic sytems
KOHLER, Stefan $71,201 $7,614 3 Yr(s) BSC
University of Western Ontario
Medial temporal-lobe contributions to novelty detection and recognition memory
KORNELUK, Robert G $125,946 3 Yr(s) G
Children's Hospital of Eastern Ontario (Ottawa)
The X-linked inhibitor of apoptosis (XIAP): A therapeutic agent for the treatment of muscular dystrophy
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
47

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
KOSZYCKI, Diana BRADWEJN, Jacques / FLAMENT, Martine
 $71,503 3 Yr(s) CHI
University of Ottawa
University of Ottawa Institute of Mental Health Research
Children at risk for panic disorder
KOVALCHUK, Olga $112,604 $19,850 3 Yr(s) GSH
University of Lethbridge (Alberta)
Sex differences in radiation-induced oncogenic signalling: Uncovering the mechanisms and biological significance
KREPINSKY, Joan $76,500 3 Yr(s) EM
McMaster University
Akt as a possible mediator of glomerular sclerosis in diabetic nephropathy
KRISTOF, Arnold S $103,248 $8,332 3 Yr(s) RS
McGill University
Signaling mechanisms of lung epithelial cell activation and apoptosis during the innate immune response
KRONSTAD, James W $130,082 $12,189 5 Yr(s) MI
University of British Columbia
Morphogenesis of fungal pathogens
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
48

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
KRUEGER, Paul D $156,114 $8,970 3 Yr(s) SDA
McMaster University
Relocation into long-term care: Understanding the tragectory, process, needs, lived experiences, impact and outcomes of relocation on older adults and their family caregivers
KUMAR, Rakesh KUNIMOTO, Dennis Y $105,564 3 Yr(s) PS
University of Alberta
Studies on novel anti-tuberculosis agents
KUMAR, Ujendra $118,043 3 Yr(s) E
McGill University
Processing and intracellular targeting of prosomatostatin peptides
KVIETYS, Peter R $130,465 $20,500 5 Yr(s) CSC
London Health Sciences Centre Res. Inc. (Ont.)
Erythropoietin protects the heart from ischemia/reperfusion injury
LABELLE, Hubert B FELDMAN, Debbie / FORTIER, Isabel / GOULET, Lise / GRIMARD, Guy / ROSSIGNOL, Michel
 $63,467 $6,700 3 Yr(s) HSR
Hôpital Sainte-Justine (Montréal)
Caractérisation du patron de référence en orthopédie et étude des facteurs associés à l'intervention chez les patients atteints de scoliose idiopathique de l'adolescence
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
49

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
LACROIX, André BOURDEAU, Isabelle / HAMET, Pavel / TREMBLAY, Johanne
 $134,957 5 Yr(s) E
Centre Hosp. de l'Université de Montréal (CHUM)
Aberrant expression of hormone receptors in adrenal Cushing's Syndrome
LALA, Peeyush K $89,938 5 Yr(s) E
University of Western Ontario
Biology of the feto-maternal interface
LAMARCHE, Benoît DODIN, Sylvie / LEMIEUX, Simone
 $91,249 2 Yr(s) NUT
Université Laval
Milk consumption and the metabolic syndrome in menopausal women
LAMBERT, Marie DELVIN, Edgard E / HANLEY, James A / LEVY, Emile H / O'LOUGHLIN, Jennifer L / PARADIS, Gilles
 $95,281 2 Yr(s) M
Hôpital Sainte-Justine (Montréal)
Obesity and cardiovascular risk factors in children and adolescents
LANG, Bernd F $164,122 $32,991 5 Yr(s) GMX
Université de Montréal
Comparative, functional genomics in mitochondria: A combined bioinformatics and biochemical approach
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
50

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
LAPOINTE, Normand D LEVY, Joseph J / OTIS, Joanne / SAMSON, Johanne / TROTTIER, Germain
 $92,204 $4,521 2 Yr(s) CHI
FERNET, Mylène
Hôpital Sainte-Justine (Montréal)
Adolescents infectés par transmission verticale : significations de l'expérience avec le VIH/sida et processus par lesquels elles se construisent
LAUTT, W. Wayne $113,515 3 Yr(s) M
University of Manitoba
Pharmacology of meal-induced insulin sensitization
LAVALLEE, Michel $82,260 3 Yr(s) CSC
Montréal Heart Institute
Endothelin-1 and myocardial O2 supply/demand mismatch in normal and heart failure dogs
LAVOIE, Josée N $148,045 5 Yr(s) MCC
Université Laval
Hôtel-Dieu de Québec
Cell death mechanisms in transformed cells
LAZARUS, Alan H $113,264 3 Yr(s) EM
St. Michael's Hospital (Toronto)
Mechanism of action of anti-CD44 antibodies in the amelioration of murine ITP
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
51

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
LE MELLEDO, Jean-Michel ARCHER, Stephen L / BAKER, Glen B / GYENES, Gabor / NEWMAN, Stephen C / TSUYUKI, Ross T
 $106,894 $73,195 3 Yr(s) BSB
University of Alberta
University of Alberta Hospital (Edmonton)
Major depression, cardiovascular risk, and selective serotonin reuptake inhibitors (SSRIs)
LEDUC, Richard ESCHER, Emanuel / KLARSKOV, Klaus / LAVIGNE, Pierre
 $124,124 5 Yr(s) E
Université de Sherbrooke
Molecular mechanisms of urotensin II function
LEE, Chong S DOUDET, Doris J $116,457 3 Yr(s) BSA
PHILLIPS, Anthony G
University of British Columbia
Neural mechanisms underlying response changes to levodopa in Parkinson's Disease
LEES-MILLER, Susan P BEATTIE, Tara L $109,480 3 Yr(s) CPT
University of Calgary
The role of the DNA-dependent protein kinase (DNA-PK) at telomeres
LEHNER, Richard VANCE, Dennis E $150,502 3 Yr(s) M
University of Alberta
Role of triacylglycerol hydrolase in lipid metabolism
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
52

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
LEMIRE, Bernard D $130,891 $19,932 5 Yr(s) BMA
University of Alberta
Biogenesis of the mitochondrial respiratory chain: Assembly and structure of yeast SDH
LEPAGE, Martin JOOBER, Ridha / PRUESSNER, Jens
 $109,687 $19,632 4 Yr(s) BSB
MALLA, Ashok K
Douglas Hospital Research Centre (Verdun, Québec)
Neural and cognitive correlates of persistent negative symptoms in patients with first-episode psychosis
LESLIE, William D GREENBERG, Cheryl R / LIX, Lisa M / METGE, Colleen J / O'NEIL, John D / TENENHOUSE, Alan M / WEILER, Hope A
 $160,846 4 Yr(s) CIB
University of Manitoba
First Nations Bone Health Study (FNBHS) - longitudinal measurements and outcomes
LEVINGS, Megan K $62,867 3 Yr(s) IT
University of British Columbia
Vancouver Coastal Health Research Institute
The foxP3 transcription factor as a tool for monitoring and modulating peripheral tolerance
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
53

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
LEVY, Emile H DELVIN, Edgard E $110,999 4 Yr(s) EM
Hôpital Sainte-Justine (Montréal)
Intestinal scavenger receptor class B Type I (SR-BI): Topology on brush-border membrane, regulatory mechanisms and role in cellular cholesterol metabolism
LEYGUE, Etienne $128,662 3 Yr(s) E
University of Manitoba
Exploration of the functions and roles of the steroid receptor RNA activator (SRA) protein in breast cancer
LI, Karen Zown-Hua PENHUNE, Virginia B $47,352 3 Yr(s) BSC
Concordia University (Montreal, Quebec)
Age-related differences in concurrent motor and cognitive performance: An investigation of neuronal and cognitive compensation
LI, Ren-Ke FAZEL, Shafie $147,615 5 Yr(s) CSB
University Health Network (Toronto)
Toronto General Hospital
The interplay of recruited stem cells and the matrix after myocardial infarction: Shifting the balance toward repair
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
54

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
LIANG, Chen $93,612 3 Yr(s) VVP
Sir Mortimer B. Davis Jewish General Hospital- Mtl
Lady Davis Institute for Medical Research (Mtl)
Role of RNA helicase A in HIV-1 replication: Identification of gag-associated cellular factors
LILGE, Lothar $72,953 $2,100 4 Yr(s) BME
University Health Network (Toronto)
Ontario Cancer Institute (Toronto)
Delivery improvements for photodynamic therapy
LIN, Tong-Jun $117,018 5 Yr(s) IT
Dalhousie University (Nova Scotia)
Mechanisms and regulation of igE-dependent mast cell activation
LINGARD, Lorelei A BAKER, G. R / BOHNEN, John M / DORAN, Diane M / ESPIN, Sherry / ORSER, Beverley A / REZNICK, Richard K / ROTSTEIN, Lorne / TAN, Jens
 $61,548 $3,995 5 Yr(s) HSR
REGEHR, Glenn
Hospital for Sick Children (Toronto)
University of Toronto
Team talk II: A multi-institutional evaluation of a checklist intervention to structure communication and promote patient safety in the operating room
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
55

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
LIPPÉ, Roger $107,591 $7,050 2 Yr(s) VVP
Université de Montréal
Molecular analysis of herpes simplex Type 1 egress
LIU, Fei-Fei JURISICA, Igor / REILLY, Raymond M
 $140,063 4 Yr(s) CPT
University Health Network (Toronto)
Ontario Cancer Institute (Toronto)
The next generation of gene transfer therapy for human nasopharyngeal cancer
LIU, Jun $118,227 3 Yr(s) MI
University of Toronto
Mycobacterial cell wall: Biosynthesis and roles in pathogenesis and antibiotic resistance
LOBAUGH, Nancy J MCINTOSH, Anthony R $97,801 $7,500 5 Yr(s) BSC
STANISZ, Greg J
Sunnybrook and Women's College Health Sciences Ctr
Quantitative imaging of brain white matter: A path to understanding the development of brain communication
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
56

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
LOEB, Mark B DREBOT, Michael A / ELLIOTT, Susan J / EYLES, John D / FEARON, Margaret A / HANNA, Steven E / MAHONY, James B / NICOLLE, Lindsay E / RATHBONE, Michel P
 $100,865 3 Yr(s)
9 Mths
 PUB
McMaster University
Long term impacts of severe West Nile virus infection: A cohort study
MACGOWAN, Christopher K YOO, Shi-Joon $69,093 $5,000 3 Yr(s) BME
Hospital for Sick Children (Toronto)
MRI assessment of pulmonary hemodynamics within the lungs
MACLEOD, Kathleen M MCNEILL, John H $77,142 $4,500 3 Yr(s) CSA
University of British Columbia
Abnormalities of signaling pathways in diabetic cardiomyopathy: Implications for new treatment
MACPHERSON, Andrew J $135,078 5 Yr(s) IT
McMaster University
Mechanisms of intestinal igA induction and protection of adults and neonates against the commensal intestinal bacterial flora
MADSEN, Karen L $104,504 3 Yr(s) EM
University of Alberta
Role of probiotic bacteria in modulating epithelial and immune function
* Research Institute is displayed only when different from the institution Paid.
** PRC = Peer Review Committee
57

Principal Investigators
Institution Paid
Research Institution*
Title
 Co-Applicant(s) Average Annual Operating Amount
 Equipment Term PRC **
Status
MAGER, Dixie L $127,700 5 Yr(s) IT
University of British Columbia
B.C. Cancer Research Centre (Vancouver)
Regulation of natural killer cell receptor genes
MAGER, Dixie L $142,986