DSEN Research agenda

The table below lists the DSEN queries that are currently active and under research, including the subject, phase (where applicable) and methodology.

Subject Method
Isotretinoin-related congenital malformations Observational studies
Comparative Effectiveness of anti-Tumor Necrosis Factor agents versus traditional Disease-Modifying agents in reducing orthopedic surgery in rheumatoid arthritis Comparative effectiveness
Safety of Inhaled Corticosteroid Use in Children and in Pregnancy (active Surveillance and Evaluation of Adverse Reactions in Canadian Healthcare Active Surveillance
5-HT3 Antagonists (Antiemetics) & Cardiac Safety (phase 2) Active surveillance & pharmacogenomics
How do atypical antipsychotics such as olanzapine and risperidone compare to clozapine in terms of effectiveness and safety (and ideally cost-effectiveness) for the treatment of schizophrenia? Network meta-analysis
How do thiazide diuretics compare to ACE inhibitors and combination antihypertensive products in terms of effectiveness (and cost-effectiveness) for the management of hypertension in non-diabetic patients? (phase 1) Network meta-analysis
How do thiazide diuretics compare to ACE inhibitors and combination antihypertensive products in terms of effectiveness (and cost-effectiveness) for the management of hypertension in non-diabetic patients? (phase 2) Comparative effectiveness
How does real world use of insulin glargine compare to NPH insulin in terms of effectiveness and safety (and ideally cost-effectiveness) for the management of type 1 diabetes mellitus? (phase 2) Comparative effectiveness
What is the real world comparative effectiveness, safety, and (ideally cost-effectiveness) of varenicline, bupropion, and nicotine replacement therapy for smoking cessation? (phase 2) Network meta-analysis
Stalevo and risk for heart attack, stroke, and cardiovascular death Network meta-analysis
The effects of Disease-Modifying AntiRheumatic Drugs (DMARD) Comparative effectiveness
Is quetiapine use associated with a higher risk of serious cardiomyopathies among patients diagnosed with schizophrenia, bipolar and major depressive disorder? Observational studies
Levetiracetam and Developmental Toxicity Network meta-analysis
Evaluation of clinical consequence of elevated prolactin levels in pediatric patients exposed to risperidone compared to other atypical antipsychotics (OAA). Network meta-analysis
Association between newer antidepressants and Persistent Pulmonary Hypertension of the Newborn (PPHN) Comparative effectiveness
Darunavir congenital malformations in HIV pregnancy Network meta-analysis
Comparative effectiveness
Domperidone use in Parkinson’s Disease: risk of serious cardiac events Observational studies
OxyContin vs OxyNEO: what is the effectiveness of abuse-deterrent opioid formulations at preventing abuse related outcomes (e.g. addiction, diversion, accidental overdoses or mortality, etc.) compared to non-abuse-deterrent opioid formulations? Observational studies
Effectiveness and Safety Concerns of Newly Approved Protease Inhibitors (boceprevir and telaprevir) for the Treatment of Chronic Hepatitis C Active surveillance & pharmacogenomics
Safety of incretin-based therapies with regards to incidence of pancreatitis and / or pancreatic cancer Observational studies
Comparative effectiveness of pharmacological treatments for rheumatoid arthritis Network Meta-Analysis
New oral anticoagulants for the treatment of venous thromboembolic events Network Meta-Analysis
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