Peer Review Committees and Mandates - Open Operating Grant Program (OOGP)

The following table presents an alphabetized list of peer review committees and their corresponding mandates for CIHR's Open Operating Grant Program. When applying for funding, you should suggest up to two committees whose mandates most closely align with your research project. Note that many of the peer review committee mandates have recently been revised. Please review the committee mandates before applying in order to correctly identify the best committees to review your application

If you require more information in order to suggest an appropriate peer review committee, you may query the CIHR Funded Research Database by research subject, to see which committee reviewed projects similar to yours. The detailed list of query results includes information on the project title, assigned peer review committee, abstract, amount of funds awarded and period of funding.

Committee Examples of Research Covered CIHR Contact
Aboriginal Peoples' Health (ABH)

Disciplinary and interdisciplinary approaches to aboriginal health research. Ethical, cultural, mental, physical, social, psychological, spiritual, environmental, genetic determinants and/or aspects of illness and wellness in aboriginal populations. Aboriginal Health services, policy development and knowledge translation. Aboriginal world view of health and well-being that includes balancing mental, physical, spiritual and emotional aspects; investigating indigenous knowledge, traditional medicine, spiritual health.

The committee reviews applications using the full range of relevant disciplinary methodologies, with an emphasis on the integration of advanced health research methods with community-based approaches, multi-sectoral partnership models, participatory action research, and indigenous methodologies. Investigations that contribute to capacity-building for both the advanced health research community and aboriginal populations are encouraged. Community capacity-building encouraged by the Committee could include, but not be limited to: inclusion of a community member on the research team, hiring of community-based research assistants, establishing a Community Advisory Group and describing its role throughout the duration of the research process, inclusion of community-based dissemination strategies for research findings, signing of a research protocol with participating communities, involvement of community members in development of a program-based intervention and including a sustainability plan for the intervention once the research is completed.

Note: Applicants must refer to the Guidelines for Health Research Involving Aboriginal People.

DL
Behavioural Sciences - A (BSA)
(Behavioural Studies in Animal Models)
Basic behavioural studies (usually in animal models) investigating mechanisms of psychiatric or neurological disorders, motivation, reinforcement, ingestive behaviour, drug self-administration, learning, neuroplasticity, neurodegeneration/neuroprotection, recovery of function, circadian rhythms, stress, epilepsy; the genetic bases of behaviour; neuro- and behavioural pharmacology; neuro- and behavioural endocrinology; neuro- and behavioural immunology; and related research. Methodologies used include but are not restricted to behavioural testing, lesions, electrophysiological recordings, drug administration, biochemical assays, imaging, genetic analyses and manipulations, molecular biology techniques, etc. DL
Behavioural Sciences - B (BSB)
(Clinical Behavioural Sciences)
Clinical/applied studies in psychiatric or neurologic populations of ADHD, schizophrenia, bipolar disorder, anxiety, depression, mood disorders, personality disorders, autism, intellectual disabilities, obsessive-compulsive disorder, behavioural aspects of alcohol and/or drug addiction, and other psychiatric or behavioural conditions; neuropsychiatry/neuropsychology; behavioural neurology. Methodologies used include but are not restricted to behavioural testing, imaging, genetic analyses, biochemical assays, electrophysiological recordings, drug administration, etc. DL
Behavioural Sciences - C (BSC)
(Behavioural Studies and Neural Imaging)
Basic studies, using cognitive, systems, or behavioural neuroscience approaches (in humans or animal models), of cognition, attention, memory, sensory and motor functions/integration, perception, sleep, pain, speech/language; neuropsychology. Methodologies used include but are not restricted to behavioural testing, psychophysics, electrophysiological recordings, imaging, molecular/cellular techniques, neuroanatomy, neurocontrol of gait, eye movement recordings, computational neuroscience, etc. DL
Biochemistry & Molecular Biology - A (BMA) Structural biology. Biophysical investigations of macromolecules. Membrane proteins and/or bioenergetics (including relevant lipids). Enzymology and enzyme mechanisms. JW
Biochemistry & Molecular Biology - B (BMB)

Studies on molecular mechanisms of biological systems using biochemistry and molecular biology, with a focus on nucleic acid and protein function. In particular: chromatin, chromosomes, organelles; mechanisms and regulation of DNA and RNA metabolic processes and information transfer (e.g. replication, recombination, repair, transcription, processing, splicing, transport, translation).

Notes: Studies with a primary focus on the structure of protein or nucleic acids should be referred to the Biochemistry & Molecular Biology - A (BMA) committee, and studies with a primary focus on development should be referred to the committee on Developmental Biology (DEV).

JW
Biological & Clinical Aspects of Aging (BCA) Cellular mechanisms of aging, cell senescence, cellular response to stress. Longevity genes and senescence genes. Mechanisms of exceptional aging, premature aging syndrome. Animal models of aging. Predictive markers of biological health and aging. Molecular and cellular basis of age-related changes in tissues and systems (e.g., osteoporosis and osteoarthritis, age-related decline in immune function, changes in sleep and biological rhythms). Causes, prevention, and treatment of geriatric syndromes, including falls, frailty and functional decline, immobility, delirium, incontinence. Management of chronic pain. Cognitive decline in the elderly. ML
Biomedical Engineering (BME)

Biomechanical and medical devices including prosthetic devices and artificial organs. Organ and tissue preservation. Numerical models of physiological systems. Biomaterials. Biomechanics. Regenerative medicine, tissue engineering, repair and regeneration.

Note: Gait studies, biomechanical studies dealing with movement, studies with a focus on rehabilitation for movement disorders, should be referred to the committee on Movement & Exercise (MOV).

GH
Cancer Biology & Therapeutics (CBT) Carcinogenesis. Basic and translational aspects of DNA repair, cell cycle/checkpoints, vaccine, and gene therapy. Radiation biology. Experimental radiotherapy. Cancer immunotherapy. Innovative tumour markers. Cancer prevention approaches. JW
Cancer Progression & Therapeutics (CPT) Cancer progession biomarkers, including angiogenesis and host/tumour microenvironment modifications. Development of innovative pharmacological agents and targets. Molecular targeting therapies. Exploratory translational cancer research. Molecular epidemiology of innovative tumour markers. JW
Cardiovascular System - A (CSA)
(Cells & Tissues)
Research on the heart at the levels of tissues and cells: electrophysiology, metabolism, molecular biology, cardiac muscle, cell biology. Genetic studies, ion channels, molecular signaling in cardiology, cardiac development, and cardiac tissue cell culture. ML
Cardiovascular System - B (CSB)
(Basic translational research in Cardiovascular Sciences)

Research on the heart and circulation: hemodynamics, hypertension, myocardial protection, cardiac remodeling, myocardial ischemia and reperfusion, neuro- and endocrine regulation. Studies cellular and animal models of human cardiac disease. Genetic models of cardiovascular disease states, including pharmacogenomics, gene discovery and gene expression studies.

Note: Clinical and clinically-relevant studies should be referred to the Clinical Investigation-D (CID) committee.

ML
Cardiovascular System - C (CSC)
(Vascular System)
Research on the vascular system, including the endothelium, with an emphasis on the cellular, molecular, and immune mechanisms that regulate cardiovascular function in normal and disease states. Atherosclerosis, inflammation, and thrombosis. ML
Cell Biology & Mechanisms of Disease (CBM)

Cell biology and cellular mechanisms of diseases. Post-natal stem/progenitor cell growth and differentiation, somatic cell survival and death, cell-cell and cell-substratum adhesion, cell-cell interactions and communications, cell signalling, organelle dynamics, cytoskeleton multi-functions, endo- and exocytosis, protein trafficking, and protein quality control. Experimental models of diseases, cellular pathology and molecular defects.

Notes: Studies on embryonic stem cells should be referred to the committee on Developmental Biology (DEV). Structural biology studies should be referred to the Biochemistry & Molecular Biology - A (BMA) committee, and studies focused on gene regulation and transcription to the Biochemistry & Molecular Biology - B (BMB) committee. Studies on obesity should be referred to the committee on Diabetes, Obesity, Lipid & Lipoprotein Disorders (DOL). Studies on spinal cord injury and repair should be referred to the committee on Neurosciences (NSA/NSB).

JW
Cell Physiology (CP)

Signal transduction. Cytoskeleton. Cell cycle. Differentiation. Ion channels. Bioenergetics. Membrane structure and function. Transport mechanisms. Secretion mechanisms.

Notes: Studies related to skeletal muscle contraction should be referred to the committee on Movement & Exercise (MOV). Studies related to cardiac muscles should be referred to the committee on Cardiovascular System - A (CSA).

JW
Clinical Investigation - A (CIA)
(Reproduction, Maternal, Children and Youth Health)

Clinical and clinically-relevant studies on reproductive, maternal, foetal, neonatal, infant, child and youth health.

Note: Studies related to social and developmental aspects of children's and youth's health, should be referred to the Social & Developmental Aspects of Children's & Youth's Health committee (CHI).

ML
Clinical Investigation - B (CIB)
(Arthritis, Bone, Skin and Cartilage)

Clinical and clinically-relevant studies in arthritis, bone, cartilage and dermatology; joint diseases and rheumatology; orthopaedics; wound healing; bone and mineral metabolism; oral and craniofacial structures.

Note: For applications related to dental and oral health research, also refer to NSA, DEV and MI.

GH
Clinical Investigation – C (CIC) Clinical and clinically-relevant studies in metabolic and endocrine disorders; gastroenterology, hepatology, nephrology, urology, haematology and related viral and microbial pathologies. DL
Clinical Investigation - D (CID)
(Translational Research in Cardiovascular Sciences)
Clinical and clinically-relevant studies on the heart and circulation: hemodynamics, hypertension, myocardial protection, cardiac remodeling, myocardial ischemia and reperfusion, neuro- and endocrine regulation. Physiological Studies. Cardiovascular clinical pathophysiology, diagnosis and therapeutics, clinical genetic studies including genotype and phenotype studies, arterial and venous vascular disease. ML
Developmental Biology (DEV)

Molecular genetics of development, control of gene expression during development. Pattern formation, cell determination and differentiation in development, specification of tissue type, targeted disruptions of developmental control genes, the roles of transcription factors and growth factors in development, regulatory hierarchies of gene expression, cell-cell communication and signal transduction in development, post-transcriptional controls of developmental processes such as regulated splicing and protein modification. Regulation and differentiation of embryonic stem cell populations. Developmental neurobiology. Morphogenesis. Embryology. Teratology.

Notes: DEV will review applications related to the developmental aspects of the oral function. Studies related to neuronal stem cell biology should be referred to the Molecular & Cellular Neurosciences (NSB) committee.

DL
Diabetes, Obesity, Lipid & Lipoprotein Disorders (DOL)

Molecular, cellular and whole organism studies of carbohydrate, lipid and energy metabolism as related to both fundamental and translational biology of diabetes, obesity, insulin resistance and dyslipidemia. Protein Metabolism.

Note: Population studies and human studies related to nutritional aspects of obesity and diabetes, or the relation between diet and health should be referred to the committee on Nutrition, Food & Health (NUT). Studies on the immunology of type 1 diabetes should be referred to the committee on Immunology and Transplantation (IT).

DL
Endocrinology (E)

Cellular and molecular biology of endocrine organs/tissues and mechanisms underlying endocrine disorders, including those related to hormones and cancer, as well as cardiovascular, neuroendocrine and renal systems.

Male and female reproductive endocrinology, and hormonal basis of fertility control and infertility. Gonads and the hormonal control of gametogenesis. Developmental endocrinology. Hormonal regulation/control of pregnancy and parturition as well as puberty and aging.

Examples of study areas include: regulation of peptide and polypeptide hormone synthesis/processing and receptors; steroid hormone synthesis/metabolism, binding proteins and receptors; hormone signaling pathways and regulation of target genes; mechanisms of hormone action and endocrine disruption; development and/or differentiation of endocrine cells; biochemical and genetic/molecular basis of endocrinopathies.

Note: Studies related to diabetes should be referred to the committee on Diabetes, Obesity, Lipid & Lipoprotein Disorders (DOL).

ML
Haematology, Digestive Disease & Kidney (HDK)

Studies of mechanisms of disease including cellular physiology and molecular biology with a special interest in translational research. The focus on disease in the following systems: haematology, gastroenterology and hepatology, nephrology, and urology.

Note: Clinical and clinically-relevant studies should be referred to the Clinical Investigation-C (CIC) committee.

DL
Gender, Sex & Health (GSH)

How sex (i.e., biological factors) and gender (i.e., sociocultural conditions/experiences) influence health status, health behaviour, and health services use. The interaction of sex and gender with other determinants of health (e.g., income, education, culture, official language minority status, ability, environment, geography). Sex differences and gender influences, alone or in combination/interaction with other factors, on the health of females and males across the life span.

Applicants must demonstrate the use of gender and sex-based analysis (GSBA) in their applications. To learn more about GSBA, please refer to the CIHR Grants and Awards Guide.

Note: Clinical and clinically-relevant studies having a primary focus on reproductive and maternal health should be referred to the Clinical Investigation - A (CIA) committee. Studies related to male and female reproductive endocrinology, and hormonal basis of fertility control and infertility, should be referred to the Endocrinology (E) committee.

DL
Genetics (G) Inherited disease and disease susceptibility; mutation and mutational mechanisms; modeling of human genetic disease; genotypes, phenotypes and natural history of genetic disease; metabolic genetics; population and statistical genetics; cytogenetics; epigenetic inheritance and gene regulation; genetics of DNA repair, replication and recombination; gene and gene based therapies. JW
Genomics (GMX) Technical or conceptual advances in genome research related to genome mapping, genotyping technologies and high-throughput methodologies such as next generation sequencing. Conceptual and technical advances in meta-genomic analysis, model organisms, functional genomics; including molecular systems-level analysis that apply several large-scale, genome-wide techniques. Application of synthetic biology approaches to genome research and advances in proteomics, epigenomics or bioinformatics as they relate to any of these problems. JW
Health Policy & Systems Management Research (HPM)

Health policy and politics. Health economics (e.g., health economic evaluation, health system financing, health remuneration methods and health resource allocation mechanisms). Health systems management (e.g., health administration, health organizational behaviour and governance, health systems analysis, integrated health systems, and managed health care). Health human resources (e.g., structure/organization of health professions and availability of appropriate health professionals to provide necessary services to disadvantaged populations).

Notes: Studies in which the primary focus is on children and youth, the elderly, or gender issues should be referred to the committees on Social & Developmental Aspects of Children's & Youth's Health (CHI), Social Dimensions in Aging (SDA), or Gender, Sex & Health (GSH).

GH
Health Services Evaluation & Interventions Research (HS1)

Effectiveness and efficiency of health services at the individual, community, and population levels. Research into the delivery of all health services given by health professionals and others, including improving access to care for disadvantaged populations. Evidenced based practice. Care provider issues. Primary care, home care, quality of care, effectiveness, efficiency, and equity of interventions. Population health interventions, defined as policies, programs, resource distribution approaches that have the potential to improve health outcomes at the population level.

Notes: Applicants should also read the mandate of the committee on Knowledge Translation Research (KTR). Studies in which the primary focus is on children and youth, the elderly, or gender issues should be referred to the committees on Social & Developmental Aspects of Children's & Youth's Health (CHI), Social Dimensions in Aging (SDA), or Gender, Sex & Health (GSH).

GH
Humanities, Social Sciences, Law & Ethics in Health (HLE)

Health research from the humanities (including but not limited to history, philosophy, law, literary studies, cultural studies, narrative analysis, arts based or performance research, communication or media analysis) or social sciences (including but not limited to health studies, sociology, anthropology, religious studies, political science). Research in health ethics (e.g. clinical ethics, research ethics) and health law. Research proposals can be critical, theoretical, methodological or empirical in nature, in accordance with disciplinary standards.

Notes: A number of other peer review committees (including those listed in this note) are also appropriate for social sciences and humanities research and should be considered by applicants. Studies having a primary focus on health services or evaluation of services should be referred to the Health Services Evaluation & Interventions Research (HS1) committee. Studies related to determinants of health should be referred to the Psychosocial, Sociocultural & Behavioural Determinants of Health (PB1) committee. Studies with an emphasis on health policy should be referred to Health Policy & Systems Management Research (HPM). Studies related to population and public health should be referred to the Public, Community and Population Health (PH1) committee. Studies in which the primary focus is on children and youth, the elderly, or gender issues should be referred to the committees on Social & Developmental Aspects of Children's & Youth's Health (CHI), Social Dimensions in Aging (SDA), or Gender, Sex & Health (GSH). Studies related to palliative care should be referred to the committee on Palliative and End of Life Care (PLC).

GH
Immunology & Transplantation (IT) Research in host innate and adaptive immunity at the molecular, cellular, whole animal or human levels. Developmental, genetic and cell biology studies with a primary focus on immune cells and their molecules (e.g. antibodies, cytokines). Systems biology of immune responses. Studies on inflammatory and/or immune-mediated diseases (autoimmune diseases, allergy, hypersensitivity responses) emphasizing immune pathogenesis rather than target organ injury or function. Cell and solid organ transplantation and induction of tolerance. Studies on novel immunotherapies such as vaccines and biologicals when emphasizing novel immune mechanisms. JW
Knowledge Translation Research (KTR) Research directed toward developing theory, evidence and innovation to define the determinants, implementation and uptake of health research evidence into practice. Research on: determinants of knowledge application, effectiveness of interventions to promote knowledge application, and evaluation and impact of knowledge application on health and other patient outcomes, professional practice, and policy. ML
Medical Physics & Imaging (MPI) Development and application of physical methods in medicine and biology including imaging methods, computerized applications, radiation therapy and radiation biophysics. GH
Microbiology & Infectious Diseases (MID) Molecular microbiology and microbial physiology with an emphasis on (non-viral), bacterial, fungal and parasite pathogenesis and host-pathogen interactions including the study of virulence factors. Diagnosis and therapy of infectious diseases; vaccine discovery and development. Antimicrobial mechanisms and resistance. Drug discovery and new therapeutics including alternates to antibiotics such as probiotics and phage therapy. Mechanisms of immune evasion by pathogens, acting either on innate or adaptive arms of the immune response with a focus on the pathogen. Systems biology of organisms and diseases. Contributions of microbes to health and development of the host. JW
Molecular & Cellular Biology of Cancer (MCC) Mechanistic analysis of cancer etiology and discovery research relating to fundamental tumourigenic processes such as angiogenesis, cell cycle/proliferation, stem cell fate/differentiation, growth regulation, apoptosis and metastasis. Includes studies of gene expression, signal transduction, cancer genomics and use of model organism and molecular genetic approaches. JW
Movement & Exercise (MOV)

Gait studies, biomechanics. Skeletal muscle biology, fibre typing and regulation. Skeletal muscle contraction. Movement disorders, neuromuscular disorders, myopathies. Sensory motor integration. Exercise physiology, role of exercise in health promotion and rehabilitation. Rehabilitation and physical therapy. Orthopaedics applied to the articular system. Occupational ergonomics. Kinesiology. Health and physical fitness.

Note: Studies related to cardiac muscles should be referred to the Cardiovascular System - A (CSA) committee.

GH
Systems & Clinical Neurosciences (NSA)

Studies focused on systems neuroscience and the description of the circuitry underlying conscious and autonomic behaviour. Projects may focus on neural networks, neural computation, network dynamics or integrated neural circuitry. Motor, sensory, homeostatic, neuroregulatory systems and associated disorders, including epilepsy, Alzheimer's disease, Parkinson's disease and stroke. Studies on disorders of the senses, including vision, hearing and pain.

Notes: NSA will review applications related to orofacial neurophysiology. Studies on neuroembryology, neurogenesis and gliogenesis or the regulation of stem cell populations should be referred to the committee on Developmental Biology (DEV). Studies on molecular and cellular neurosciences, developmental neurobiology, neurotransmitters and signaling molecules, cellular and molecular mechanisms of neurological disorders should be referred to the committee on Molecular & Cellular Neurosciences (NSB). Studies related to skeletal muscle, myopathies, kinesiology and exercise should be referred to the committee on Movement & Exercise (MOV).

DL
Molecular & Cellular Neurosciences (NSB)

Axonal and dendritic development; synaptogenesis and activity-dependent development; developmental cell death; development of motor, sensory and limbic systems; differentiation of neuronal stem cells. Neurotransmitters and signaling molecules; ligand- or voltage-gated ion channels; G-protein linked receptors; neurotransmitter release; synaptic transmission and synaptic plasticity; neuronal excitability. Cellular and molecular mechanisms of neurological disorders.

Note: Studies on neuroembryology, neurogenesis and gliogenesis or the regulation of stem cell populations should be referred to the committee on Developmental Biology (DEV). Studies on neural networks, neural computation, network dynamics, clinical and system neuroscience, and sensory systems should be referred to the committee on Systems & Clinical Neurosciences (NSA). Studies related to skeletal muscle, myopathies, kinesiology and exercise should be referred to the committee on Movement & Exercise (MOV).

DL
Nutrition, Food & Health (NUT) Human nutrition through the life span. Dietetics. Obesity, including evaluations of new glucose and weight-lowering drugs. Energy balance and nutrition. Health consequences of specific diets and dietary supplements, nutritional factors in the etiology of metabolic and gastrointestinal disorders, the epidemiological association between dietary habits and disease incidence. Food intolerance and allergy. Nutrition-related education and health promotion. Diabetes prevention and education. The influence of socioeconomic, cultural, and political factors on nutrition of the individual and the community. The impact of nutrient intake on disease response, work performance, and behaviour. Population and life cycle nutrient use and requirements. Pathogenesis of nutrient imbalance. Non-oral feeding strategies. Food production techniques, and food handling and safety. Probiotics. Nutrigenetics and nutrigenomics. DL
Palliative & End of Life Care (PLC) Epidemiological studies and surveys of problems related to palliative and end of life care; the development of methods for the early detection, prevention and management of suffering associated with life-limiting illness and prolonged morbidity resulting from any disease; studies on medical, physical, psychosocial and spiritual approaches to the minimization of pain and other symptoms for both patients and families; research into training for families and other caregivers in innovative communication and decision-making processes; health services research, including the development of novel methods and tools; research into the promotion of knowledge translation through informed policies and clinical practices aimed at improving the quality and dignity of life for the patients. The committee will also review proposals that address critical evaluation of ethical, legal, economic and moral issues pertaining to the utilization of health care resources and the quality of care. JW
Pharmaceutical Sciences (PS) Research on drug design and delivery. Medicinal chemistry, radio-pharmaceuticals, biopharmaceutics and drug analyses. Pharmacognosy. Pharmacokinetics. ML
Pharmacology & Toxicology (PT) Research on drug metabolism and toxicology. Drug abuse and addiction. Mechanisms of drug action. Characterization of drug targets. Pharmacology of biological substances. Clinical pharmacology. Pharmacogenetics. ML
Psychosocial, Sociocultural & Behavioural Determinants of Health (PB1)

Behavioural and social science research applied to health, health behaviour, quality of life, psychophysiology, and community health including, but not limited to, hypothesis-testing and clinically applied projects. Behavioural, social, and cultural factors, as they relate to health, disease, and biomedical treatments. Individual and population perspectives can be adopted. Projects address these issues from the perspective of the social, health professional and behavioural sciences, emphasizing a priori hypotheses, prospective designs, and psychometric measurement criteria as well as qualitative studies.

Notes: Studies with a primary focus on child and youth development, familial, parental and social influences on the health of children and youth should be referred to the committee on Social & Developmental Aspects of Children's & Youth's Health (CHI). Studies with a primary focus on the elderly should be referred to the committee on Social Dimensions in Aging (SDA). Studies where gender issues are a primary focus should be referred to the committee on Gender, Sex & Health (GSH). Studies dealing with questions of human values in health care contexts should be referred to the committee on Humanities, Law, Ethics & Society in Heath (HLE).

DL 
Public, Community & Population Health - (PH1)

The conception and measurement of exposures and health status and the testing of hypotheses concerning exposure/disease relationships. The mandate includes the development or application of novel statistical methods. Research on the etiology of human disease and disability. The measurement of burden of disease in populations, ranging from gene/environment interactions in the biological origins of disease to the impact of social environments, including disadvantaged populations' status, on health and functional status. Work and health. Health inequalities and gradients. Health of diverse and disadvantaged populations. Water safety. Impact of global change on health. Population health interventions, defined as policies, programs, resource distribution approaches that have the potential to improve health outcomes at the population level.

Notes: Studies with a primary focus on child and youth development, familial, parental, and social influences on the health of children, should be referred to the committee on Social & Developmental Aspects of Children's & Youth's Health (CHI). Studies with a primary focus on the elderly should be referred to the committee on Social Dimensions in Aging (SDA). Studies where gender issues are a primary focus should be referred to the committee on Gender, Sex & Health (GSH). Studies with a focus on nutrition or food safety should be referred to the committee on Nutrition, Food & Health (NUT).

GH
Randomized Controlled Trials (RC1)

Studies in which investigators randomly assign eligible research participants or other units of study (e.g., classrooms, clinics, playgrounds) into groups to receive or not receive one or more interventions that are being compared. The results are analyzed by comparing outcomes in the groups. The RCT panel is multidisciplinary across the spectrum of CIHR's mandate.

Note: For applications for randomized controlled trials: (1) researchers may suggest the most relevant discipline-based peer review committee or the RC1 peer review committee if the budget requested is less than $250,000 in every project year, and in all cases, CIHR will decide on the most appropriate peer review committee based on committee mandate and expertise required for the review; and (2) the application will be sent to the RC1 committee for review if the overall budget requested is greater than or equal to $250,000 in any project year. In all cases, CIHR will decide on the most appropriate peer review committee based on expertise required for the review. All applications reviewed by the RC1 committee, regardless of the level of funding requested, must follow the RCT headings provided under RCT Evaluation Criteria and Headings. If these headings are not used in the Research Proposal, the application will be withdrawn. All applications for RCTs that are reviewed by discipline-based committees are encouraged to use the RCT headings but are not required to do so. Use of the RCT headings allows for the provision of the information required for the RCT review.

GH
Respiratory System (RS) Destructive and obstructive lung disease. Lung mechanics. Pulmonary circulation. Sleep-related disorders. Lung and associated tissue. Respiratory diseases of the newborn. Nonmicrobial diseases of the adult. Surfactant. Respiratory control mechanisms. Airway smooth muscle. Neurocontrol of breathing. Acute lung injury. Lung inflammation. Asthma and allergies. Determinants of respiratory diseases (gene-environment interactions). ML
Social & Developmental Aspects of Children's & Youth's Health (CHI)

Conditions for optimizing child and youth health, development and well being. Prevention, treatment, and strategies for support of children and youth with physical, mental, congenital and behavioural health challenges. The effects of environmental exposures on reproductive and child and youth health. Environmental, life style and social influences on maternal, foetal, neonatal, infant, child and youth health. Health impacts and outcomes of family environment, family dynamics and childhood care; parenting; attachment patterns; impacts of poverty; violence and abuse. Specific childhood and youth-related conditions: causal, risk and prognostic factors prevention, early identification, treatment, and long-term management, with consideration of school-related issues and issues related to the official language minority status.

Note: Studies related to biological and clinical aspects of children's and youth's health should be referred to the Clinical Investigation - A (CIA) committee or other system-specific committees.

ML
Social Dimensions in Aging (SDA) Social factors as determinants of health and quality of life in aging (e.g., social support, work, participation of the elderly persons in society, leisure and recreation, household and family structure, housing, transportation, economic status and inequality, retirement). Positive health behaviours, and healthy life styles, physical activity. Life-course interactions and transitions. Long-term care and caregiving for the elderly, including assisted or supportive living facilities, care at home. Health services for the elderly, including those living in rural, northern, and official language minority communities. Palliative care: pain management, individual and family support, choice of settings and implications of choices, strategies for implementing end-of-life guidelines. Health status of the elderly population. Studies of social factors affecting specific age-related physical, cognitive, communications, behavioural, and mental health problems. Elder abuse and neglect. ML
Virology & Viral Pathogenesis (VVP) Virology. Immunology as related to viruses. Diagnosis and therapy of viral diseases. Antiviral resistance. JW

Key to CIHR contacts:

DL Mrs. Dominique Lalonde
Tel.: 613-954-1813
Email: dominique.lalonde@cihr-irsc.gc.ca
GH Dr. Gregory Huyer
Tel.: 613-954-1816
Email: gregory.huyer@cihr-irsc.gc.ca
JW Dr. James Waring
Tel.: 613-948-2699
Email: james.waring@cihr-irsc.gc.ca
ML Dr. Martine Lafrance
Tel.: 613-941-4643
Email: martine.lafrance@cihr-irsc.gc.ca
Fax: 613-954-1800