The Bhagirath Singh Early Career Award in Infection and Immunity 2014 Recipient
Dr. Bebhinn Treanor
Department of Biological Sciences
University of Toronto Scarborough
Dr. Treanor's research interests
Dr. Treanor studies the molecular mechanisms of B cell activation. B cells are an essential part of the immune system as they are the cells producing antibodies, which bind to pathogens such as bacteria, viruses, or damaged cells, and by doing this, help destroying them for the benefit of the host. For B cells to produce antibodies, they must undergo a process of activation, which is triggered upon recognition of the pathogen. The molecular mechanisms involved in the activation process require the coordinated assembly of several molecules into a spatially distinct compartment within the cell. Dr. Treanor is trying to identify the molecular mechanisms which organize these spatially discrete regions of activation, using cutting edge imaging techniques to visualize these processes in live cells. These studies are not only important for understanding how to efficiently activate B cells to produce antibodies, but also because dysregulation of B cell activation can result in B cell malignancies or autoimmune disease.
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