Personalized Medicine research profiles
Dr. John Bell
Dr. John Bell and his team have been investigating cancer-fighting (oncolytic) viruses at Ottawa Hospital Research Institute for more than 10 years.
Researchers from the Ottawa Hospital Research Institute (OHRI), the University of Ottawa (uOttawa), Jennerex Inc. and several other institutions reported promising results of a world-first cancer therapy trial in renowned journal Nature.
The trial is the first to show that an intravenously-delivered viral therapy can consistently infect and spread within tumours without harming normal tissues in humans.
- Dr. Lynne-Marie Postovit - New therapeutic target for breast cancer
Breast cancer continues to be one of the most commonly diagnosed cancers among Canadian women. Dr. Lynne-Marie Postovit and her team at the Western University have identified a protein called Nodal – primarily found in patients with aggressive breast cancer tumors. The study, published in the journal Cancer Research, indicates that when this protein is targeted, the blood vessels in the tumor collapse, depleting oxygen levels and ultimately causing tumor cell death.
- Dr. Nada Jabado - Genomics research identifies childhood cancer genes
With the introduction of next-generation sequencing techniques, research now has the ability to identify disease causing genes. In fact, Dr. Nada Jabado and her team have been able to determine which mutations are driving the growth and spread of disease. Focusing on pediatric cancers, they have uncovered genetic abnormalities that cause tumor cells to grow, or even, become resistant to treatment in pediatric glioblastoma, a deadly brain tumour. This discovery has the potential to lead to more tailored treatment for this cancer. Using these technologies, we will soon be able to better understand the origin of several diseases including other types of cancer, and the reason(s) for their progression or resistance to therapies. Vast amounts of clinical, biological and sequencing data are now being generated by an expanding number of research efforts on a scale that we could only dream of a few years ago. These endeavors are expected to bring a major shift in clinical practice in terms of diagnosis and understanding of diseases, ultimately enabling personalized medicine based on one's genome and/or the genome of the tumour.
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